role of the Leydig cells in testicular development in the rat
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role of the Leydig cells in testicular development in the rat a pharmacological approach. by Zesmin Fauzia Dewan

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Published by University of Manchester in Manchester .
Written in English


Book details:

Edition Notes

Manchester thesis (Ph.D.), School of Biological Sciences.

ContributionsUniversity of Manchester. School of Biological Sciences.
The Physical Object
Pagination464p.
Number of Pages464
ID Numbers
Open LibraryOL16571044M

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A tumor with a mixture of 2 or more types of cells has a possible common embryonic origin. 11 Moreover, several previous studies have suggested that rat testicular stromal precursor cells can develop in both Sertoli and Leydig cell directions during tumor formation. 2, 5, 7, 13 Therefore, the origin of the neoplastic Leydig cells in the present case is likely primitive gonadal stromal precursor by: 5. Part of the Contemporary Endocrinology book series (COE) During development two or three distinct populations of Leydig cells arise sequentially. These cell populations appear to represent distinct cell lineages and show clear differences in their regulation and pattern of by: 2. In the rat, testosteroneproducing fetal Leydig cells are replaced postnatally during puberty by a proliferating pool of adult Leydig cells that are needed to support spermatogenesis (Ge et al., ). Sertoli cells, the somatic cells that support germ cells within the seminiferous epithelium. Morphological studies on the rat testis have revealed a specific ultrastructural coupling of macrophages and Leydig cells. Namely, Leydig cells project slender cytoplasmic processes towards deep coated channels of macrophages. The channels are limited by an electron dense part of the macrophage by:

  Loss of the Leydig cells in the rat testis after administration of the specific Leydig cell toxicant ethane dimethane sulfonate leads to the formation of a completely new population of Leydig cells within a couple of months (2, 3).Cited by: 8. "Leydig cells have been classified as one of the main targets for phthalate ester toxicity, as both insulin-like growth factor and testosterone are suppressed after phthalate exposure". Yup, you read that right this stuff goes DIRECTLY after the leydig cells in your testicles! Start studying Pharm Physio Ch. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Search. Treating a male fetus with antibodies to DHT would prevent development of the epididymides. The Leydig cells of the testes constitute a blood-testes barrier that prevents autoimmune destruction of the sperm.   The total steroid content per Leydig cell was highest on Day of gestation (77 ng/10 6 cells). A decline started already in utero, and reached a nadir of 5 ng/10 6 cells on Day Thereafter, a slight increase occurred with advancing age. It is concluded that: 1) The fetal testis has highest Leydig cell and endogenous steroid Cited by:

ited the proliferation of Sertoli cells during testicular development and produced a rat with smaller than normal testes Propylthiouracil was used to inhibit thyroid hormone action during development and this treatment resulted in rats with larger than normal testes Hemicastration of developing testes . Testicular ghrelin gene expression was demonstrated throughout postnatal development, and ghrelin protein was detected in Leydig cells from adult testis specimens. Accordingly, ghrelin mRNA signal. testosterone-producing Leydig cells. Testosterone supports the maturation of sperm and maintains the male phenotype. Functional Leydig cells are therefore required to prevent testicular malfunction. Yet in contrast to their well-established role in the testis, the origin of the adult Leydig cell lineage has largely remained : Luise Landreh. Abstract. A morphometric study of rat testis development and ageing (from 5 to days of age) has been carried out. The testicular volume increases from +/- mm3 (5 days of age) to +/- mm3 ( days of age), showing the most rapid increase between 20 and 70 days of Cited by: