by Huddersfield Polytechnic .
Written in English
|Contributions||Polytechnic, Huddersfield. Department of Chemical Sciences.|
Beta lactamases are enzymes produced by some bacteria that destroys the beta lactam ring of the antibiotic (PCN's, cephalosporins, carbapenems, and monobactams) - this action of the bacteria can be chromosomal (encoded in the genes) or due to a plasmid (extra-chromosomal structure that can be passed from one species to another). β-Lactam antibiotics mimic the terminal d-Ala-d-Ala moiety of the reactive β-lactam ring is able to acylate the active serine residue of the transpeptidase, leading to a stable acyl–enzyme intermediate that is still appended with a bulky substituent (the second ring of the β-lactam antibiotics), thus preventing the access of an incoming amino group, required to achieve. Purchase The Biology of B-Lactam Antibiotics - 1st Edition. Print Book & E-Book. ISBN , Book Edition: 1. b-lactams synthesis and antibacterial activity. Penicillins, cephalosporins, and certain other antibiotics belong to a family of compounds, collectively known as b-lactam antibiotics, which share the structural feature of a b-lactam the penicillins the b-lactam ring is fused to a five-membered thiazolidine ring, whereas the cephalosporins display a fused b-lactam/dihydrothiazine ring.
eBook is an electronic version of a traditional print book THIS can be read by using a personal computer or by using an eBook reader. (An eBook reader can be a software application for use on a computer such as Microsoft's free Reader application, or a book-sized computer THIS is used solely as a reading device such as Nuvomedia's Rocket eBook. Beta-lactam antibiotics include penicillins, cephalosporins and related compounds. As a group, these drugs are active against many gram-positive, gram Cited by: The pharmacokinetics of antibiotics in the obese remain largely unknown, though it is evident that they diverge significantly from those in the non-obese. 26,27 Obese patients may have reduced total exposure of orally administered antibiotics, while most antibiotic classes demonstrate an increased volume of distribution in this population. Though obesity is associated with an increase in Cited by: Immediate hypersensitivity reactions to beta-lactam antibiotics. Saxon A, Beall GN, Rohr AS, Adelman DC. Allergic reactions to the beta-lactam antibiotics (penicillins, cephalosporins, carbapenems, and monobactams) are a major factor limiting their use. Immediate hypersensitivity reactions to penicillins depend on the presence of preformed Cited by: